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Localized and Advanced ER-Positive Breast Cancer


Localized and Advanced ER-Positive Breast Cancer

Topic: Oncology/ Hematology
Relevant Terms: Breast Cancer
Primary Audience: The intended audience is practicing Medical Oncologists; Hematology-Oncologists; Surgical Oncologists; Radiation Oncologists; Pathologists; Oncology Advanced Practice Nurses and Nurse Practitioners; and Oncology Physician Assistants
Launch Date: 14-Nov-12
Credits: AMA PRA Category 1 Credit
Expiration Date: The accreditation for this activity has expired.
Patients Seen:  Michelle Janice
Curriculum Name: Localized and Advanced ER-Positive Breast Cancer

Learning Objectives

After completing this activity, the participant will demonstrate the ability to:

  1. Assimilate new clinical trial evidence into the therapeutic algorithm for localized and advanced ER-positive breast cancer.
  2. Consider the influence of age and comorbid illness on breast cancer treatment outcomes, and integrate this information into individualized treatment selection. 
  3. Recall the design of ongoing clinical trials to aid in the referral of eligible patients for study participation. 


    William Audeh, MD
    Medical Director
    Samuel Oschin Comprehensive Cancer Institute
    Wasserman Breast Cancer Risk Reduction Program
    Saul and Joyce Brandman Breast Center
    Cedars-Sinai Medical Center
    Los Angeles, CA
    Monica Mita, MD
    Experimental Therapeutics Program
    Associate Professor of Medicine
    Department of Hematology and Oncology
    Samuel Oschin Comprehensive Cancer Institute
    Cedars Sinai Medical Center
    Los Angeles, CA
    Philomena F. McAndrew, MD
    Internal Medicine, Hematology and Oncology
    Associate Clinical Professor of Medicine
    Cedars-Sinai Medical Center
    University of California, Los Angeles
    Los Angeles, CA
    Sponsored by
    Cedars-Sinai Medical Center and Educational Concepts Group, LLC
    Supported by an educational grant from Novartis


    Program Overview
    In recent years, significant progress has been made in breast cancer therapy, a cornerstone of which has been the incorporation of estrogen receptor (ER)/progesterone receptor (PR)-directed therapy into the treatment paradigm for hormone-positive disease. The critical importance of ER and PR in the development and progression of breast cancer, and the association of reduced expression of those receptors with poor response to antiestrogen therapy and worse prognosis, are well known. Currently, a large amount of clinical data exploring new single and combined therapies to inhibit the PI3K/AKT/mTOR pathway is constantly emerging. In order to offer optimal patient care, clinicians must be well informed of these advances. 
    Target Audience
    Practicing Medical Oncologists, Hematology-Oncologists, Surgical Oncologists, Radiation Oncologists, Pathologists, Oncology Advanced Practice Nurses and Nurse Practitioners, and Oncology Physician Assistants.
    Accreditation Statement
    Cedars-Sinai Medical Center is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
    Credit Designation
    Cedars-Sinai Medical Center designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
    Disclosure Policy Statement
    It is the policy of Cedars-Sinai Medical Center to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. Cedars-Sinai Medical Center assesses conflict of interest with its faculty, planners and managers of CME activities. Conflicts of interest that are identified are resolved by reviewing that presenter's content for fair balance and absence of bias, scientific objectivity of studies utilized in this activity, and patient care recommendations.
    While Cedars-Sinai Medical Center endeavors to review faculty content, it remains the obligation of each physician or other healthcare practitioner to determine the applicability or relevance of the information provided from this course in his or her own practice.
    When asked to report relevant financial relationships with commercial interests, faculty reported the following:
    William Audeh, MD: No relevant financial relationships to disclose. 
    Philomena F. McAndrew, MD: No relevant financial relationships to disclose. 
    Monica Mita, MD: Speakers Bureau Genentech (Non-Commercial Trials) 
    The materials for this activity were peer reviewed and the reviewer had no relevant financial relationships to report.
    Instructions for Participating in This Activity and Obtaining CME Credit
    There are no fees for participating in and receiving CME credit for this online educational activity.
    How To Receive Credit
    By reviewing the course content and successfully completing the post-test and evaluation, physicians are entitled to receive 1.0 AMA PRA Category 1 Credit™. Statement of credit will be available to print from your user history page.
    • Read the learning objectives and faculty disclosures
    • Participate in the activity
    • Complete the post-test and activity evaluation
    • Physicians who successfully complete the post-test and evaluation will receive CME credit
    • All other participants who successfully complete the post-test and evaluation will receive a certificate of participation
    COURSE FORMAT: Internet CME Activity
    Google Chrome for Windows, Mac, or Linux
    Internet Explorer 7.0+ for Windows
    Mozilla 1.4+ for Windows, Mac, or Linux
    Firefox 3.5+ for Windows, Mac, or Linux
    Safari 4.0+ for Mac
    Release Date: 11/14/2012
    Expiration Date: 11/13/2013
    Estimated Time To Complete: 60 minutes
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