Optimizing Management of Patients with Chronic Myelogenous Leukemia: Therapeutic Strategies Making A Difference

Title:

Optimizing Management of Patients with Chronic Myelogenous Leukemia: Therapeutic Strategies Making A Difference

Topic: Oncology/ Hematology
Relevant Terms: Chronic Myelogenous Leukemia
Primary Audience: hematologists/oncologists who treat or manage patients with CML; oncology nurses; oncology nurse practitioners; physician assistants; oncology pharmacists.
Launch Date: 01-Aug-14
Credits: AMA PRA Category 1 Credit
Expiration Date: 01-Aug-15
Curriculum Name: Optimizing Management of Chronic Myelogenous Leukemia: A Community-Focused, Clinical Looking...

Learning Objectives

After completing this activity, the participant will demonstrate the ability to:

  1. Apply mutational testing strategies to inform optimal treatment and monitoring of CML patients 
  2. Explain and interpret molecular response criteria in CML
  3. Identify and define what constitutes poor response, resistant disease, disease intolerance, and strategies to overcome these challenges
  4. Apply evidence-based updates for selecting optimal treatment for first-line and second-line therapy including when to consider combination and maintenance options
  5. Implement best-practice recommendations for improving patient compliance to oral therapy
  6. Evaluate recent trial data on current and novel agents and incorporate newly available treatment options for patients with CML 
  7. Compare and contrast the safety, tolerability, and clinical outcomes of all options now available for the treatment of patients with CML

    Faculty

    Jerald P. Radich, MD
    Fred Hutchinson Cancer Research Center
    University of Washington
    Amit Verma, MD
    Associate Professor, Department of Medicine (Oncology)
    Associate Professor, Department of Developmental & Molecular Biology
    Albert Einstein College of Medicine
    Director, Division of Hematologic Malignancies
    Montefiore Medical Center
    Bronx, New York
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    This activity is jointly provided by Albert Einstein College of Medicine of Yeshiva University and AXIS Medical Education
     
    MEDIUM: CME Enduring Material Virtual Grand Rounds
     
    Estimated Time To Complete This Activity: 1.0 hour
     
    INTENDED AUDIENCE
    This activity is intended for hematologists/oncologists who treat or manage patients with CML. A secondary audience is oncology nurses, oncology nurse practitioners, physician assistants, and oncology pharmacists.
     
    STATEMENT OF NEED
    Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cells. Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of CML by effectively targeting the BCR-ABL oncogenic kinase. Many questions remain regarding the use of first, second, and third generation TKI agents in the management of CML and how to best utilize these available treatments in the front and second line settings, through combination approaches and through maintenance therapy options. Further, despite their profound activity, a substantial proportion of CML patients develop intolerance to therapy or resistant disease. The optimal choice of treatment for patients with CML represents an area of uncertainty among clinicians. The advent of mutational testing and analysis has opened the gateway toward more individualized treatment and offers clinicians with insights regarding appropriate therapeutic choices for certain patients.  It is now imperative that clinicians treating CML patients understand how to utilize this information to monitor for disease response, identify optimal timing and need for switching therapies, and communicate the importance of the patient’s role in compliant treatment to maximize clinical benefit. 
     
    DISCLOSURE POLICY STATEMENT
    The "Conflict of Interest Disclosure Policy" of Albert Einstein College of Medicine requires that faculty participating in any CME activity disclose to the audience any relationship(s) with a pharmaceutical or equipment company. Any presenter whose disclosed relationships prove to create a conflict of interest, with regard to their contribution to the activity, will not be permitted to present.
     
    The Albert Einstein College of Medicine also requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product, or device, not yet approved for use in the United States.
     
    The CCME staff of Albert Einstein College of Medicine of Yeshiva University has no conflicts of interest with commercial interests related directly or indirectly to this educational activity.

    The following AXIS planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity: Linda Gracie-King, MS, Jocelyn Timko, BS, Diedrea White, BA, Deborah Middleton, MS, and Timothy DiChara, PhD hereby state that they or their spouse/life partner do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this activity of any amount during the past 12 months.
     
    FACULTY DISCLOSURES
    The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

    Jerald P. Radich, MD reported a financial interest/relationship or affiliation in the form of: Grants/Research Funding: Novartis Pharmaceuticals Corporation
    Consultant: Ariad Pharmaceuticals, Inc., Novartis Pharmaceuticals Corporation.
     
    Dr. Radich has indicated that his relationships will not impact his ability to author an unbiased presentation.
     
    Amit Verma, MD reported a financial interest/relationship or affiliation in the form of:
    Speakers’ Bureau: Celgene
     
    UNLABELED OR INVESTIGATIONAL PRODUCT DISCUSSION:
    The faculty have indicated that this enduring material does not include the unlabeled/investigational use of a commercial product or device.

    ACCREDITATION STATEMENT
    This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Albert Einstein College of Medicine of Yeshiva University, Montefiore Medical Center and AXIS Medical Education. Albert Einstein College of Medicine of Yeshiva University is accredited by the ACCME to provide continuing medical education for physicians.
     
    AMERICANS WITH DISABILITIES ACT
    In compliance with the Americans with Disabilities Act, we will make every reasonable effort to accommodate your request. For any special requests, please contact AXIS at 954-445-0760.

    CREDIT DESIGNATION
    Albert Einstein College of Medicine of Yeshiva University designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
     
    FUNDING ACKNOWLEDGEMENT
    This activity is supported by an educational grant from Bristol-Myers Squibb Company.
     
    DISCLAIMER
    The opinions and recommendations expressed by faculty in this activity are their own and do not necessarily represent the views of Albert Einstein College of Medicine of Yeshiva University, Montefiore Medical Center, AXIS Medical Education or RealCME.

    Participants are advised to consult prescribing information for all specific drugs or combination of drugs, including indications, contraindications, warnings, and adverse effects, before administering pharmacologic therapy to patients.
     
    METHOD OF PARTICIPATION AND RECEIVING CME CREDIT
    There are no fees for participating in and receiving credit for this activity. The participant must read the learning objectives, faculty disclosures and enduring material, and must answer the multiple-choice online post-test, and evaluation form which provides each participant with the opportunity to comment on the quality of the instructional process, the perception of enhanced professional effectiveness, the perception of commercial bias, and his/her views on future educational needs.

    Upon successful completion of the post-test with a passing grade of 70%, and the evaluation, physicians will receive CME credit and all other healthcare professionals will receive a certificate of participation. A certificate will be available to print from your user history page.
     
    RELEASE DATE: August 1, 2014
     
    TERMINATION DATE: August 1, 2015 
     
    COPYRIGHT INFORMATION
    Copyright © 2014 Albert Einstein College of Medicine of Yeshiva University. All rights reserved. No part of this material may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations.
     
    PRIVACY POLICY
    Albert Einstein College of Medicine, Center for Continuing Medical Education (Einstein) protects the privacy of personal and other information regarding participants and educational collaborators. Einstein will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting purposes to the ACCME.

    Einstein maintains physical, electronic, and procedural safeguards that comply with federal regulations to protect against the loss, misuse or alteration of information that we have collected from you.

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    If you have questions about this CME activity, please contact Albert Einstein College of Medicine at 1-718-920-6674 or cme@montefiore.org.